Gastrodin Tablet

Description

Gastrointestinal Anti-inflammatory

Dosage form and packaging:

Each box contains 50 tablets.

Indications:

Anti-inflammatory and sedative for pains resulting from peptic and deudenum ulcers

Enhancement of mucous resistance

Peptic and deudenum ulcers

PHARMACOLOGIC ACTIONS

Recent analyses have shown that the extracts of the abovementioned herbs contain components affecting gastritis and ulcers of stomach and deudenum; The most crucial ones being flavonoids, saponosides, and its mucilage compounds.  Mechanism of action of  Gastrodin is a series of mechanism related to its effective matters.  Anti-ulcer effect of Glycyrrhiza glabra might be associated with stoppage of action between mucosal receptors and release of acetyl- choline of vagus nerves. In addition, it reinforces the mucous barrier against impact of gastric acid via influencing the chemical composition of stomach mucus. Mechanism of action of  flavonoids in  Glycyrrhiza glabra and calendula is also expressed based on anti-inflammatory effects of flavonoids that can prevent from release of histamines, and additionally, leave other impacts on them such as stabilization of lysosome membrane and influence on capillary permeability and strength.  Mucilage of althaea off. also has protective effects on digestive system mucus.

ACTIVE INGREDIENTS

Each Gastrodin tablet contains 400 mg of glycyrrhiza glabra root extract (whose glycyrrhizin content is reduced as far as possible) and extract of calendula off. flowers as well as althaea off root powder.

ADMINISTRATION AND DOSAGE

Observing the diet, one or two tablets before every meal for 4 to 6 weeks.

Gastrodin tablet can be prescribed solely or with anti-acid medications.

INTERACTIONS

Gastrodin has interaction with medicines which can lower potassium such as Thiazide duretics and laxatives that contain senna.

ADVERSE REACTIONS

Intake of total root and extract of licorice in  long term, would result in elevated blood pressure and occurrence of mineralocorticoid symptoms due to presence of high glycyrrhizin . For the same reason, to minimize this side effect, Gastrodin tablet is made of Glycyrrhiza glabra extract  with  the lowest amount of glycyrrhizin.

CONTRAINDICATIONS & PRECAUTIONS

The medicine shall not be used in cases of acute renal failures, chronic hepatitis, biliary duct obstruction, liver cirrhosis , and hypokalemia.

In patients suffering from hypertension, Gastrodin shall be used with doctor’s advice and control of blood pressure.

PREGNANCY AND LACTATION

It is contraindicated.

TIPS

The instances of analogous drugs already used in Iran are: Ulcedal, Rabro, Vigastrin, and Caved-s.

STORAGE

Store below 30°C and protect from moisture and light.

IRC

1228022661

REFERENCES

1) Afchar D. Cave A. etVaquette J.: Plantes Medicinales et phytotherapie, Tome XVIII, No.2, 1987, 170-174

2) Afchar D. Cave A. Guinaudeau et Vaquette: Plantes medicinales et phytotherapie, Tome XVIII, No. 2, 1984, PP. 55-61.

3) Afchar D. Cave A. Vaquette J.: Plantes medicinales et phytotherapie, Tome XIV, No. 1,1980, 46-50.

4) Avramova S. et al. Marigold (calendeula off.), Mbi, 4, 1988, PP.24-26.

5) Bezangar L.:Les plantes dans la therapeutique moderne, 1975, PP. 114-116,253-255.

6) British herbal Pharmacopoeia, 1983, 44-45, 22-23, P. 104.

7) British Parmaceutical¬¬ Codex, 1979, 497-98.

8) Duke J. A.: Handbook of medicinal herbs, CRC, 1988, 87-88,215-216.

9) Hunnius pharmazeut. Woterbuch, 1986, 196,455.

10)Lieutaghi P.: Le Livre des bonnes herbs.1983,196-197.

11)Rynolds J. E. F.:Martindale, The Extra Pharmacopoeia, 1982,691-692.

12) Merck Index: 1989, 1723, 708, 4400.

13) Rote List: 1993, 59051, 59142, 59079.

14) Tyler E.:Pharmacogonosy, philadelphia,1988,480.

15) Tierra M.:The way of herbs,1983,184-185.

16)Valent J.:Phytotherapie, 1979,667-668.

17) Vidal: 1988, 290, 278.

18) Weiss R. F.:Lehrbuch der Phytotherapie, 1985,85-87.

19)Yasuo Ishii,:Mechanism of gastric,antisectory activity of a new fraction of licorice root(FM 100).C. A. Vol, 73,2428 b,(1970).

20)Zargari A.:Medicinal plants, 1998, Vol. 1,647-55.

21) British pharmacopoeia 2011, Appendix XVIB, XIM.

22) Iranian herbal pharmacopoeia, 1381, 520-527.

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