Platelet Aggregation inhibitor
Effective in gastrointestinal cancer prevention
Allium Sativum exerts antiatherogenic , lipid – lowering , antihypertensive , antiaggregatory , vasodilatory , antioxidant , antiviral and tumour growth inhibiting effect . The effects are primarily due to allicin and transformation product . The drug may decrease systolic pressure in the elderly by reducing the amount of cholesterol deposited on the blood vessel linings. The allicin and oligosulfides have antiplatelet activity through inhibition of ADP, collagen and beta – thromboglubin release after collagen stimulation. Allium sativum reduces radicals liberated by cigarette smoke. The antioxidant effect of 1 mg of garlic powder is comparable of that of 30 nmol of vit. C or 3.6 nmol vit. E. Studies indicated that the drug act as a natural antibiotic with broad – spectrum antimicrobial activity against many genera of bacteria ( Bacillius , Escherichia , staphylococcus , streptococcus , vibrio , pseudomonas , mycobacteria ) , fungi , and even viruses .
In general, the drug has been recommend for prevention and treating cardiovascular disease , Treatment of elevated blood lipid levels insufficiently influenced by diet , Preventative measures for age – dependent vascular changes and atherosclerosis , Used for upper respiratory tract infections , Reducing of risk for stomach and colorectal cancer .
Standardized Allium sativum (Garlic) powder: 400 mg (equivalent to 1100 mcg allicin).
ADMINISTRATION AND DOSAGE
For treatment: 2-3 tablets (3-5 mg of allicin) daily, after meal.
For prophylaxis: 1 tablet daily. (Note: the dosage is ONLY for adults)
It may induce cytochrome p450 2E1 and reduces the effectiveness of drugs metabolized through this enzyme.
In rare cases gastro–intestinal irritation, allergic reactions, headache, myalgia , fatigue and vertigo observed .
CONTRAINDICATIONS & PRECAUTIONS
It may induce cytochrome p4502E1 and reduce the effectiveness of drugs metabolized through this enzyme. Allium-S tablet must be stopped 10 days before operations and surgeries.
PREGNANCY AND LACTATION
This medicine is contraindicated during pregnancy because of bleeding risk.
There is no documents about using during lactation.
Allium-S tablet must be stopped 10 days before operations and surgeries.
Store below 30˚C and protect from moisture and light.
1- Blumenthal M. ;The ABC Clinical guide to herbs,(2003), 153-170.
2- Commission E monographs: (1998), 134,505,517.
3- Martindale, 33th ed.( 2002) , 1611.
4-Newall C.A., et al; Herbal Medicines, (1996), 129-133.
5-PDR for Herbal Medicine,Fourth ed.(2008), 345-357 .
6- European Scientific Cooperative On Phytotherapy (E/S/C/O/P) ( 2003 ) , 14-25 .